Publications
| Year | Publications (Peer Reviewed Publications) |
|---|---|
| 2021 | Ding Y, Zhong Y, Baldeshwiler A, Abner EL, Bauer B, Hartz AMS. Protecting P-glycoprotein at the blood-brain barrier from degradation in an Alzheimer's disease mouse model. Fluids Barriers CNS. 2021 Mar 6;18(1):10. Read More >> |
| 2021 | Storck SE, Hartz AMS, Pietrzik CU. The Blood-Brain Barrier in Alzheimer's Disease. Handb Exp Pharmacol. 2021 Feb 13. Read More >> |
| 2021 | Koren SA, Hamm MJ, Cloyd R, Fontaine SN, Chishti E, Lanzillotta C, Rodriguez-Rivera J, Ingram A, Bell M, Galvis-Escobar SM, Zulia N, Di Domenico F, Duong D, Seyfried NT, Powell D, Vandsburger M, Frolinger T, Hartz AMS, Koren J 3rd, Axten JM, Laping NJ, Abisambra JF. Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy. Int J Mol Sci. 2021 Jan 26;22(3):1186. Read More >> |
| 2021 | Jomura R, Akanuma SI, Bauer B, Yoshida Y, Kubo Y, Hosoya KI. Participation of Monocarboxylate Transporter 8, But Not P-Glycoprotein, in Carrier-Mediated Cerebral Elimination of Phenytoin across the Blood-Brain Barrier. Pharm Res. 2021 Jan;38(1):113-125. Read More >> |
| 2021 | Chai AB, Hartz AMS, Gao X, Yang A, Callaghan R, Gelissen IC. New Evidence for P-gp-Mediated Export of Amyloid-β PEPTIDES in Molecular, Blood-Brain Barrier and Neuronal Models. Int J Mol Sci. 2020 Dec 29;22(1):246. Read More >> |
| 2020 | Blevins BL, Vinters HV, Love S, Wilcock DM, Grinberg LT, Schneider JA, Kalaria RN, Katsumata Y, Gold BT, Wang DJJ, Ma SJ, Shade LMP, Fardo DW, Hartz AMS, Jicha GA, Nelson KB, Magaki SD, Schmitt FA, Teylan MA, Ighodaro ET, Phe P, Abner EL, Cykowski MD, Van Eldik LJ, Nelson PT. Brain arteriolosclerosis. Acta Neuropathol. 2021 Jan;141(1):1-24. Read More >> |
| 2020 | Callaghan R, Gelissen IC, George AM, Hartz AMS. Mamma Mia, P-glycoprotein binds again. FEBS Lett. 2020 Dec;594(23):4076-4084. Read More >> |
| 2020 | Bauer B, Renfro JL, Karnaky KJ Jr, Masereeuw R, Fricker G, Cannon RE, Hartz AMS. David S. Miller: Scientist, Mentor, Friend-a tribute and thank you. Fluids Barriers CNS. 2020 Sep 14;17(1):56 Read More >> |
| 2020 | Lin AL, Parikh I, Yanckello LM, White RS, Hartz AMS, Taylor CE, McCulloch SD, Thalman SW, Mengfan X, McCarty K, Ubele M, Head E, Hyder F, Sanganahalli RG, APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease, Neurobiology of Disease 139:104834, 2020 Read More >> |
| 2019 | Soldner ELB, Hartz AMS, Akanuma SI, Pekcec A, Doods H, Kryscio RJ, Hosoya KI, Bauer B, Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier, FASEB Journal 33(12):13966-13981, 2019. (IF: 4.966) Read More >> |
| 2019 | Hartz AMS, Rempe RG, Soldner ELB, Pekcec A, Schlichtiger J, Kryscio RJ, Bauer B, Cytosolic phospholipase A2 is a key regulator of blood-brain barrier function in epilepsy, FASEB Journal 33(12):14281-14295, 2019. (IF: 4.966) Read More >> |
| 2018 | Rempe RG, Hartz AMS, Soldner ELB, Sokola BS, Alluri SR, Abner EL, Kryscio RJ, Pekcec A, Schlichtiger J, Bauer B, Matrix metalloproteinase-mediated blood-brain barrier dysfunction in epilepsy, Journal of Neuroscience 38(18):4301-4315, 2018 (IF: 5.988) Read More >> |
| 2018 | Ma DW, Wang AC, Parikh I, Green SJ, Hoffman JD, Chlipala G, Murphy MP, Sokola BS, Bauer B, Hartz AMS, Lin AL, Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice, Scientific Reports 8(1):6670, 2018 (IF: 4.259) Read More >> |
| 2018 | Akanuma SI, Yamakoshi A, Sugouchi T, Kubo Y, Hartz AMS, Bauer B, Hosoya KI, Major contribution of L-type amino acid transporter 1 to blood-to-retina transport of gabapentin across the blood-retinal barrier, Molecular Pharmaceutics 15(6):2327-2337, 2018. (IF: 4.396) Read More >> |
| 2018 | Hartz AMS, Zhong Y, Shen AN, Abner EL, Bauer B, Preventing P-gp ubiquitination lowers Aβ brain levels in an Alzheimer's disease mouse model, Frontiers in Aging Neuroscience 10:186, 2018. (IF: 3.633) Read More >> |
| 2018 | Hartz AMS, Schulz JA, Sokola BS, Edelmann SE, Shen AN, El Seblani N, Rempe RG, Zhong Y, Bauer B, Isolation of human brain capillaries, Journal of Visualized Experiments (139), 2018. (IF: 1.108) Read More >> |
| 2018 | Storck SE, Hartz AMS, Bernard J, Wolf A, Kachlmeier A, Mahringer A, Weggen S, Pahnke J, Pietrzik CU. The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM, Brain, Behavior and Immunity 73:21-33, 2018. (IF: 6.170) Read More >> |
| 2018 | Lee J, Yanckello LM, Ma DW, Hoffman JD, Parikh I, Thalman S, Bauer B, Hartz AMS, Hyder F, Lin AL, Neuroimaging biomarkers of mTOR effects on vascular and metabolic functions in the aging brain and Alzheimer’s disease, Frontiers in Aging Neuroscience 10:225, 2018, (Invited Review) Read More >> |
| 2017 | Hartz AMS, Pekcec A, Soldner ELB, Schlichtiger J, Bauer B, P-gp protein expression and transport activity in rodent seizure models and human epilepsy, Molecular Pharmaceutics 14(4):999-1011, 2017 (IF: 4.440) Read More >> |
| 2017 | Louie SW, Bauer B, Ronaldson PT, Hitting the BBB: Technological advancements in CNS research and drug targeting, AAPS Journal 4:14-18, 2017 (IF: 3.423), Cover Story April 2017 Read More >> |
| 2017 | Hoffman JD, Parikh I, Green SJ, Chlipala G, Mohney R, Keaton M, Bauer B, Hartz AMS, Lin AL, Age drives distortion of brain metabolic, vascular, and cognitive functions, and the gut microbiome, Frontiers in Aging Neuroscience 9(298):1-14, 2017 (IF: 4.504) Read More >> |
| 2017 | Tang F, Hartz AMS, Bauer B, Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers. Front Neurology, 8:301, 2017 Read More >> |
| 2016 | Wolf A, Bauer B, Abner EL, Ashkenazy-Frolinger T, Hartz AMS, A comprehensive behavioral test battery to assess learning and memory in 129S6/Tg2576 Mice, PLOS ONE 11(1):e0147733, 2016 (IF: 2.806) Read More >> |
| 2016 | Hartz AMS, Zhong Y, Wolf A, LeVine H, Miller DS, Bauer B, Aβ40 reduces P-glycoprotein at the blood-brain barrier through the ubiquitin-proteasome pathway, Journal of Neuroscience 36(6):1930-1941, 2016 (IF: 5.988) Read More >> |
| 2016 | Ronaldson PT, Bauer B, El-Kattan A, Shen H, Salphati L, Louie S, Highlights from the AAPS/ITC Joint Workshop on Drug Transporters in ADME: From the Bench to the Bedside - Clinical Pharmacology Considerations, Clinical Pharmacology & Therapeutics 100(5):419-422, 2016 (IF: 7.266) (Conference Proceeding) Read More >> |
| 2016 | Parikh I, Guo J, Chuang KH, Zhong Y, Rempe RG, Hoffman JD, Armstrong R, Bauer B, Hartz AMS, Lin AL, Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions, Aging 8(11):2814-2826, 2016 (IF: 4.867) Read More >> |
| 2016 | Rempe RG, Hartz AMS, Bauer B, Matrix Metalloproteinases in the Brain and Blood-Brain Barrier: Versatile Breakers and Makers, Cereb Blood Flow Metab 36(9):1481-507, 2016 Read More >> |
| 2015 | Akkaya BG, Zolnerciks JK, Ritchie TK, Bauer B, Hartz AMS, Sullivan JA, Linton KJ, The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase Nedd4-1, Molecular Membrane Biology 26: 1-7, 2015 (IF: 1.983) Read More >> |
| 2012 | Hartz AMS, Bauer B, Soldner ELB, Wolf A, Boy S, Backhaus R, Mihaljevic I, Bogdahn U, Klünemann HH, Schuierer G, Schlachetzki F, Amyloid-β contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy, Stroke 43(2):514-523, 2012 (IF: 6.158) Read More >> |
| 2012 | Wolf A, Bauer B, Hartz AMS, ABC Transporters and the Alzheimer's Disease Enigma, Frontiers in Psychiatry 3:54, 2012 (Invited Review) Read More >> |
| 2011 | Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, Leybaert L, Molnar Z, O'Donnell ME, Povlishok JT, Saunders NR, Sharp F, Stanimirovic D, Watts RJ, Drewes LR, Engaging neuroscience to advance translational research in brain barrier biology, Nature Reviews Neuroscience 12(3):169-182, 2011 (IF: 30.445) Read More >> |
| 2011 | Bauer B, Schlichtiger J, Pekcec A, Hartz AMS, The blood-brain barrier in epilepsy, Clinical and Genetic Aspects of Epilepsy, Chapter 2, 23-54, 2011, Editor: Zaid Afawi, Publisher: InTech, Invited Book Chapter |
| 2011 | Shukla S, Skoumbourdis AP, Walsh MJ, Hartz AMS, Fung KL, Wu CP, Gottesman MM, Bauer B, Thomas CJ, Ambudkar SV, Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (Nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters, Molecular Pharmaceutics 8(4):1292-1302, 2011 (IF: 4.782) Read More >> |
| 2011 | Jacob A, Hartz AMS, Potin S, Yousif S, Coumoul X, Scherrmann JM, Bauer B, Decleves X, Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels, Fluids and Barriers of the CNS 8(1):23, 1-12, 2011 Read More >> |
| 2011 | Agarwal S, Hartz AMS, Elmquist WF, Bauer B, Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up, Current Pharmaceutical Design 17, 2793-2802, 2011 (Invited Review) Read More >> |
| 2010 | Hartz AMS, Miller DS, Bauer B, Restoring blood-brain barrier P-glycoprotein reduces brain Aβ in a mouse model of Alzheimer's disease, Molecular Pharmacology 77(5):715-723, 2010 (IF: 4.725) Read More >> |
| 2010 | Hartz AMS, Mahringer A, Miller DS, Bauer B, 17B-estradiol: a powerful modulator of blood-brain barrier BCRP activity, Journal of Cerebral Blood Flow and Metabolism 30(10):1742-1755, 2010 (IF: 4.522) Read More >> |
| 2010 | Hartz AMS, Madole EK, Miller DS, Bauer B, Estrogen receptor β signaling through PTEN/PI3K/Akt/GSK3 downregulates blood-brain barrier BCRP, Journal of Pharmacology and Experimental Therapeutics 334(2):467-476, 2010 (IF: 4.017) Read More >> |
| 2010 | Bauer B, Targeting regulation of ABC transporters at the blood-brain barrier to improve pharmacotherapy of CNS disorders, International Drug Discovery, August/September Issue, 76-79, 2010 (Invited Review) |
| 2010 | Hartz AMS, Bauer B, Regulation of ABC transporters at the blood-brain barrier: new targets for CNS therapy, Molecular Interventions 10(5):293-304, 2010 (Invited Review) Read More >> |
| 2010 | Hartz AMS, Bauer B, ABC transporters of the neurovascular unit – An inventory, Current Pharmaceutical Biotechnology 12:423-440, 2011, (Invited Review) Read More >> |
| 2009 | Shukla S, Zaher H, Hartz AMS, Bauer B, Ware JA, Ambudkar SV, Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice, Pharmaceutical Research 26(2):480-487, 2009 (IF: 3.933) Read More >> |
| 2009 | Zibell G, Unkrüer B, Pekcec A, Hartz AMS, Bauer B, Miller DS, Potschka H, Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition, Neuropharmacology 56(5):849-855, 2009 (IF: 3.909) Read More >> |
| 2009 | Ott M, Fricker G, Bauer B, PXR regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR, Journal of Pharmacology and Experimental Therapeutics 329(1):141-149, 2009 (IF: 4.093) Read More >> |
| 2009 | Pekcec A, Unkrüer B, Schlichtiger J, Soerensen J, Hartz AMS, Bauer B, van Vliet EA, Gorter JA, Potschka H, Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation, Journal of Pharmacology and Experimental Therapeutics 330(3):939-947, 2009 (IF: 4.093) Read More >> |
| 2009 | Hartz AMS, Notenboom S, Bauer B, Signaling to P-glycoprotein – a new therapeutic target to treat drug-resistant epilepsy? Drug News & Perspectives 22(7):393-397, 2009 (Invited Review) Read More >> |
| 2009 | Stenehjem DD, Hartz AMS, Bauer B, Anderson GW, Novel and emerging strategies in drug delivery for overcoming the blood-brain barrier, Future Medicinal Chemistry 1(9):1623-1641, 2009 (Invited Review) Read More >> |
| 2008 | Bauer B, Hartz AMS, Pekcec A, Toellner K, Miller DS, Potschka H, Seizure-induced upregulation of P-glycoprotein at the blood-brain barrier through glutamate and COX-2 signaling, Molecular Pharmacology 73(5):1444-1453, 2008 (IF: 4.711) Read More >> |
| 2008 | Bauer B, Hartz AMS, Lucking JR, Yang X, Pollack GM, Miller DS, Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier, Journal of Cerebral Blood Flow and Metabolism 28(6):1222-1234, 2008 (IF: 5.741) Read More >> |
| 2008 | Hartz AMS, Bauer B, Block ML, Hong JS, Miller DS, Diesel exhaust particles induce oxidative stress, pro-inflammatory signaling, and P-glycoprotein upregulation at the blood-brain barrier, FASEB Journal 22(8):2723-2733, 2008 (IF: 7.049) Read More >> |
| 2008 | Miller DS, Bauer B, Hartz AMS, Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve CNS pharmacotherapy, Pharmacological Reviews 60(2):196-209, 2008 (Solicited Review) Read More >> |
| 2007 | Bauer B, Hartz AMS, Miller DS, TNF-alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier, Molecular Pharmacology 71(3):667-675, 2007 (IF: 4.088) Read More >> |
| 2006 | Hartz AMS, Bauer B, Fricker G, Miller DS, Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by TNF-alpha and LPS, Molecular Pharmacology 69(2):462-470, 2006 (IF: 4.469) Read More >> |
| 2006 | Bauer B, Yang X, Hartz AMS, Olson ER, Zhao R, Kalvass JC, Pollack GM, Miller DS, In vivo activation of human PXR tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation, Molecular Pharmacology 70(4):1212-1219, 2006 (IF: 4.469) Read More >> |
| 2005 | Hartz AMS, Bauer B, Baehr CH, Miller DS, Fricker G, Drug delivery across the blood-brain barrier, Current Nanoscience 1:203-209, 2005 (Invited Review) |
| 2005 | Bauer B, Hartz AMS, Fricker G, Miller DS, Modulation of P-glycoprotein transport function at the blood-brain barrier, Molecular Biology and Medicine 230(2):118-127, 2005 (Invited Review) Read More >> |
| 2004 | Hartz AMS, Bauer B, Fricker G, Miller DS, Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1, Molecular Pharmacology 66(3):387-394, 2004 (IF: 5.080) Read More >> |
| 2004 | Bauer B, Hartz AMS, Fricker G, Miller DS, Pregnane X receptor up-regulation of P-glyco-protein expression and transport function at the blood-brain barrier, Molecular Pharmacology 66(3):413-419, 2004 (IF: 5.080) Read More >> |
| 2003 | Bauer B, Miller DS, Fricker G, Compound profiling for P-glycoprotein at the blood-brain barrier using a microplate screening system, Pharmaceutical Research 20(8):1170-1176, 2003 (IF: 2.609) Read More >> |
| 2002 | Fellner S, Bauer B, Miller DS, Schaffrik M, Fankhänel M, Spruss T, Bernhardt G, Graeff C, Färber L, Gschaidmeier H, Buschauer A, Fricker G, Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo, Journal of Clinical Investigation 110(9):1309-1318, 2002 (IF: 14.051) Read More >> |
| 2001 | Nobmann S, Bauer B, Fricker G, Ivermectin excretion by isolated functionally intact brain endothelial capillaries, British Journal of Pharmacology 132(3):722-728, 2001 (IF: 3.502) Read More >> |
